Adenovirus and its Vector for Developing Vaccines Against Biological Warfare Agents

摘要

This memorandum reviews a new platform for the development of vaccines against biological warfare (BW) agents. The noted platform uses adenovirus as a vector to deliver DNA that encodes for key antigens of BW agents. Once inside the mammalian cell, this adenovirus vectored vaccine induces rapid immune responses. This memorandum describes the basic virology of adenovirus, methods used to modify adenovirus as vaccination vector, advantages of adenovirus vector for developing vaccines against BW agents such as Ebola and anthrax, and the potential obstacles, with proposed solutions, for the use of adenovirus vector.