Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement

摘要

The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer.