Development of a Web-Enabled Informatics Platform for Manipulation of Gene Expression Data

摘要

High-throughput gene expression technologies such as Affymetrix and De Novo 2-Color Microarrays generate large scale measurements that require sophisticated bioinformatic platforms for data archival, management, integration, and analysis if researchers are to derive biologically meaningful relationships from the data. The Array Repository Data Analysis System (ARDAS 1.0) at Walter Reed Army Institute of Research is a web-enabled bioinformatic platform consisting of a Laboratory Information Management System (LIMS), an Analysis Information Management System (AIMS), and a Data Warehouse which coordinates activities of the system modules that allows queries across data within the system. The system, developed following successful Phase 1 and 2 SBIRs in conjunction with our commercial partner, 3rd Millennium, Inc, provides the foundation for an innovative enterprise-wide bioinformatics solution for US Army Medical Research and Materiel Command investigators seeking to leverage array technologies to develop vaccines and drugs against diseases and biothreat agents of military importance.