Role of p53 Mutations in Metastasis of Prostate Cancer to Bone

摘要

The mortality and morbidity of prostate cancer (CaP), the commonest cancer in men in Western society, are largely caused by the spread of Cap to bone. How this occurs, and the interactions between Cap cells and bone are poorly understood. Specific mutations of the tumor suppressor gene, p53, that occur in CaP may cause disease progression. To test this, we have generated cell lines derived from the human LNCaP cell line that stably express wild type or mutantp53.