Synthesis of Acetogenin Analogs as Potential Therapeutics for Treating Prostate Cancer

摘要

Toward the objective of creating new acetogenin analogs as potential therapeutics for treating prostate cancer, all of the key substructures and building blocks have been prepared, and assembling them into the first analogs has commenced. All synthetic challenges encountered during the project thus far have been successful overcome, and work is proceeding as planned. As an additional bonus from this work, a new cobalt complex was developed that catalyzes the stereoselective oxidative cyclization of bis-homoallylic alcohols to trans-tetrahydrofurans in high yield. This new catalyst is likely to see wide spread use in medicinal chemistry.