Molecular Profiling of Intraductal Carcinoma of the Prostate.

摘要

Defined by the presence of malignant cells spreading within intact prostatic ducts and acini, intraductal carcinoma of the prostate (IDC-P) occurs almost exclusively in high Gleason grade and stage tumors and is a consistent independent risk factor for tumor progression and death. Importantly, however, IDC-P is currently systematically under-diagnosed in needle biopsies because it has significant morphologic overlap with another intraepithelial lesion, high grade prostatic intraepithelial neoplasia (HGPIN). We hypothesize that IDC-P represents progression of invasive high-risk prostate carcinoma, and thus is molecularly distinct from HGPIN. Herein, we will conduct an unbiased, three-pronged strategy to definitively identify the molecular signature of IDC-P using a combination of protein, RNA, and DNA-based assays. Then, we will exploit this data to improve pathologic recognition of IDC-P. Here, we report on the use of PTEN/ERG protein as biomarkers of IDC-P in prostate needle biopsy specimens.