Development of Practical and Rapid Field-Based Therapies for SCI.

摘要

We have designed a set of experiments to test candidate therapies for spinal cord injury (SCI) that could be applied in the battlefield and other acute traumatic settings. Specifically, we aim to optimize a combinatorial treatment to augment behavioral recovery following severe spinal cord contusion. These strategies include: 1) augmentation of the intrinsic growth state of an injured neuron by elevating cyclic AMP levels, and 2) modifying the extrinsic toxic/inhibitory spinal cord environment by transplantation of cells secreting growth factors.