Corrective 111In Capromab Pendetide SPECT Image Reconstruction Methods for Improved Detection of Recurrent Prostate Cancer

摘要

It is generally recognized that 111In capromab pendetide (PS) scans are technically challenging to perform and interpret, particularly with regard to pelvic SPECT studies used to detect possible disease I the prostate fossa and pelvic lymph node (LN). The hypothesis of this proposal is that the superior spatial resolution methods would substantially aid in the detection and diagnosis of prostate cancer. To test our hypothesis, we propose five specific aims: (1) to develop simulation tools and methods that allow efficient generation of accurate lllln PS projection data from the human pelvic area, (2) to study the effects of 3 D image degrading factors on lllln PS SPECT images, (3) to develop 3D corrective image reconstruction methods for lllIn PS SPECT that provide much improved image quality and quantitative accuracy by incorporating models of the 3D image degrading factors, (4) to evaluate the 3D corrective image reconstruction methods for clinical lllIn PS SPECT studies using simulated patient data, and Hotelling and human observer studies, and (5) to evaluate the clinical efficacy of the corrective image reconstruction methods as applied to lllln PS SPECT using patient data.