Characterization of the Human Proteomic Response to Hydrocodone: A Preliminary Study.

摘要

Non-medical use and abuse of prescription opioids is a growing problem in both the civilian and military communities. Current technologies for detecting hydrocodone use are limited. Standard drug screens do not detect hydrocodone. In order to detect the use of hydrocodone and prescription opioids for nontherapeutic purposes, it is vital to establish the excretion profile of these drugs. Currently there is no data available describing blood, urine and oral fluid profiles following administration of a 10 mg dose of hydrocodone. We will measure proteomes and metabolites in blood, urine and oral fluid samples after hydrocodone exposure. We are exposing healthy volunteers to 10 mg pure hydrocodone under controlled conditions and collecting blood, oral fluid, and urine at defined intervals up to 7 days. We included 2 subjects for control in the study giving a total of 41 participants.