Regulation of Cell Cycle by BCCIP a BRCA2 and CDKN1(p21) Interacting Protein

摘要

DAMD17-03-1-0317 is an IDEA award that focuses on the roles of BCCIP in cell cycle regulation. The approaches are over-expression and down-regulation of BCCIP by RNAi. The project has been moving on smoothly in the first 12 months. We have accomplished the scientific objectives of tasks 1-3, and 50% of tasks 4-5. We have published one paper based on this study. As an un-anticipated discovery, we have found that BCCIP also regulates p2l expression. This finding further strengthens our central hypothesis that BCCIP regulates cell cycle control. In the next funding year, we will strive to accomplish the objectives of tasks 5-6.