Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy After Traumatic Brain Injury.

摘要

Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 30 months since this grant was funded, we have completed experiments spanning nearly the whole range of our proposed work. The most important milestones in this project year have been: 1. Continued successful implementation of very challenging post-TBI in vivo two-photon imaging and in vivo whole cell recording, with manuscript in preparation of novel TBI-specific phenotypes from our in vivo whole cell recordings. 2. Novel findings from two-photon recordings. 3. Novel findings from recording of acute and chronic remote telemetry datasets. 4. Progressive implementation of histological techniques. 5. Collection of post-TBI behavioral datasets. 6. Publication of the preliminary data for this grant in Stroke.