Inflammatory Sequelae of Aortic Balloon Occlusion in Hemorrhagic Shock.

摘要

Resuscitative endovascular ballon occlusion of the aorta (REBOA) is a hemorrhage control and resuscitative adjunct that has been demonstrated to improve central perfusion during hemorrhagic shock. The aim of this study was to characterize the systemic inflammatory response associated and cardiopulmonary sequelae with 30, 60, and 90 min of balloon occlusion and shock on the release of interleukin 6 (IL 6) and tumor necrosis factor alpha. Female Yorkshire swine (Sus Scrofa) weighing 70-90 kg were entered into a study protocol consisting of the following five phases: animal preparation, induction of hemorrhagic shock (30 min), balloon occlusion (30, 60, or 90 min), resuscitation (6 h), and critical care (48h) Indices of hemo dynamic performance were recorded throughout the study, along with blood sampling at specific time points. Animals were euthanize at the end of the critical care phase and necropsy performed. Indices of hemodynamic performance were recorded throughout the study, along with blood sampling at specific time points. REBOA is a useful adjunct in supporting central perfusion during hemorrhagic shock; however, increasing occlusion time and shock results in a greater IL 6 release. Clinicians must anticipate inflammation mediated organ failure in post REBOA use patients.