Mechanism of Interaction of Sleep-Affecting Compounds With Neuronal Receptors

摘要

This report results from a contract tasking lnst of Physiologically Active Substances. Russian Academy of Sciences as follows: The goal of this project is to study the mechanism of interaction of some endogenous sleep- affecting compounds with the GABA (gamma aminobutyric acid)- and glutamate receptor channel complexes in neuronal cell culture. Electrophysiological and biochemical methods will be used to assess those interactions. Results will provide new insights into those naturally existing compounds that induce and regulate the sleep-wake cycle or affect related fatigue via key neurotransmitter systems.