Non-Immunogenic Structurally and Biologically Intact Tissue Matrix Grafts for the Immediate Repair of Ballistic-Induced Vascular and Nerve Tissue Injury in Combat

摘要

In the first two years of this work the production of decellularized and freeze-dried vascular grafts from human umbilical vessels was accomplished while substantially maintaining tissue microstructure biological activity and biomechanical properties. It was anticipated that umbilical vein and artery grafts implanted clinically would demonstrate patency as well as significant repopulation and remodeling by the surrounding host tissue. Such a graft would be a desirable alternative to current interventions for hemodialysis access; occluding non-remodeling synthetic PTFE grafts and inconsistent native fistulas, below-the-knee vessel replacement; amputation, and coronary artery bypass grafting.