Transmission Dynamics and Prospective Environmental Sampling of Adenovirus In a Military Recruit Setting

摘要

High levels of adenovirus morbidity among US military recruits have returned since the loss if the adenovirus vaccines in 1996. The transmission dynamics of adenovirus have never been well understood, complicating attempts to interrupt spread with preventive methods. Methods Enrollment and end-of- study samples were taken and active surveillance for febrile respiratory illnesses performed on 341 recruits and support personnel. Simultaneously, surface and air samples were collected. Classic cell culture, serology, and a high-throughput advanced diagnostic technique were employed in laboratory processing. Results Seventy-nine percent (213/271) of new recruits were seronegative to either adenovirus serotype 4 (Ad-4) or serotype 7 (Ad-7). Febrile respiratory illness caused by Ad-4 was captured in 25% (67/271) of enrolled recruits, with 100% occurring in individuals with enrollment titers.