Prostate Cancer Detection Using Near Infrared Spectral Polarization Imaging

摘要

Specific aims: The objective of this grant is to develop a near infrared (NIR) spectral polarization imaging technique for prostate cancer detection. The technique is based on the spectral and polarization properties of light scattered, absorbed and emitted from prostate cancerous and normal tissues, and contrast agents targeted to the prostate cancers. Results of finding and their significance: All of the six specific tasks listed in the revised work statement were performed successfully: (1) NIR spectral polarization imaging measurements were performed on human rectum-membrane- prostate tissue samples (task no. 1), and the results show that small objects hidden inside host prostate tissues can be imaged and identified through a rectum-and-membrane tissues; (2) imaging measurements of in-vitro prostate cancerous-normal tissue samples (task no. 2) based on water absorption, and a cancer-receptor-targeted contrast agent (Cybesin) were performed. The results show that the water content may be used for prostate cancer detection, and prostate cancerous tissues takes up more Cybesin agent than that of normal tissues that makes Cybesin a potential candidate maker for prostate cancer detection; (3) a breadboard rectal optical probe used for the prostate NIR scanning imaging unit was designed, built and tested (task no. 3); (4) the absorption spectra of prostate cancerous and normal tissues were measured (task no. 4), and the results show that prostate cancerous tissue has less absorption than that of normal tissue at water absorption peaks indicating cancer tissue has less water content than that of normal tissue; (5) preliminary integrating sphere measurements were performed to Investigate the difference of scattering length between prostate cancerous and normal tissue (task no. 5); and (6) steady- state and time-resolved spectral measurements for Cybesin (Task no. 6) were performed.