Role of IQGAP1 in Neoplastic Growth and Metastasis

摘要

The purpose of this proposal is to evaluate the role of IQGAPl in neoplastic transformation and metastasis of breast epithelial cells. The main emphasis is on whether IQGAPl is involved in invasion and metastasis of transformed breast epithelial cells, as well as the possible involvement of IQGAPl in regulating beta-catenin function. Major findings are: (i)there is a high level of expression of IQGAPl in breast epithelium; (ii)overexpression of IQGAPl in mammalian cells enhances cell migration and proliferation; and (iii) beta-catenin function and subcellular distribution were modulated by IQGAPl. These data reveal that IQCAPl has a fundamental role in cell motility and invasion in breast epithelium. This information could have potential therapeutic implications in patients with breast cancer.