Integrated Sensing Using DNA Nanoarchitectures

摘要

The objective of the NanoArchitectures initiative is the generation of well defined arrays of DNA capable of supporting molecular systems demonstrating switching phenomena. Parallel efforts have been in place to forward the objective of large scale structures and installation of molecular components. In particular the research has transitioned from 0D (stand alone origami) to 1D (chains of origami). Although forays into 2D (both limited structures and unlimited structures) has been performed, the emphasis is on 1D growth since defects and the source of defects may be more readily traced in 1D systems than in 2D systems. We have observed that the lengths of 1D systems far exceeds the length scale of extant 2D systems. Because there are approaches which can expand 1D systems in a second dimension, creating 2D systems (which are a pre-requisite to controlled 3D systems), our emphasis has been placed on control of 1D system growth. Yield information is much more rigorously obtained when the system is organized into arrays. Similarly, quantitative evaluation of the performance of individual nanosystems will be much improved by the organized, rather than the current, disorganized placement of such systems.