High Throughput Synthesis and Screening for Agents Inhibiting Androgen Receptor Mediated Gene Transcription

摘要

Details of the progress on our grant to define a new treatment of therapeutic resistant prostate cancer is provided. This entails the high throughput synthesis of DNA binding agents related to distamycin, their screening for binding to androgen response elements using a new high throughput DNA binding screen we introduced, and the evaluation for inhibiting androgen receptor mediated gene transcription and the cell proliferation of a prostate cancer cell line.