Cell Motility and Invasiveness of Neurofibromin-Deficient Neural Crest Cells and Malignant Triton Tumor Lines

摘要

Our purpose is to examine the role of the NFI gene product, neurofibromin, in modulating the migratory and invasive properties of neural crest cells (NOC) and neural crest-derived sarcoma cells. As a negative regulator of Ras signaling, neurofibromin may influence the responses of NO.