DRDC Ottawa Working Standard for Biological Dosimetry

摘要

This Standard provides quality assurance, quality control, and evaluation of the performance criteria for the purpose of accreditation of the Radiation Biology laboratory at Defence Research AND Development Canada - Ottawa (DRDC Ottawa) using biological dosimetry to predict radiation exposure doses. The International Standard (ISO 19238) and the International Atomic Energy Association (IAEA) Technical Report Series No. 405 are used as guiding documents in preparation of this working document specific to the DRDC Ottawa Radiation Biology Laboratory. This Standard addresses: (1) The confidentiality of personal information, for the customer and the service laboratory; (2) The laboratory safety requirements; (3) The calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves allowing the dose estimation from chromosome aberration frequency, and the minimum detection levels; (4) Transportation criteria for shipping of test samples to the laboratory; (5) Preparation of samples for analysis; (6) The scoring procedure for unstable chromosome aberrations used for biological dosimetry; (7) The criteria for converting a measured aberration frequency into an estimate of absorbed dose; (8) The reporting of results; (9) The quality assurance and quality control plan for the laboratory; and (10) Informative annexes containing examples of a questionnaire, instructions for customers, a data sheet for recording aberrations, a sample report and other supportive documents.