Plastic-Based Structurally Programmable Microfluidic Biochips for Clinical Diagnostics

摘要

The objective of this project is to develop a smart disposable polymer lab-on-a-chip for clinical diagnostics and point-of-care testing, which has the sampling/identifying capability of fast and reliable measurements of metabolic parameters from a human body with minimum invasion. The fully integrated disposable biochip is capable of precise volume control with smart microfluidic manipulation without costly on-chip microfluidic components. The biochip has a unique power source using on-chip pressurized air reservoirs, for microfluidic manipulation, avoiding the need for complex microfluidic pumps. Through the project, an innovative, fully integrated, plastic microfluidic lab- on-a-chip has been successfully developed and characterized for the dual applications of a stand-alone smart disposable polymer lab-on-a-chip as well as a wrist watch-type blood analyzer.