Skin Bioengineering: Noninvasive Transdermal Monitoring

摘要

The long-term objective is to develop and optimize a novel, noninvasive, iontophoretic approach for metabolic monitoring via the skin. The low-level current density drives both charged and highly polar (yet neutral) compounds across the skin at rates much greater than passive diffusion. As the skin offers a uniquely accessible body surface across which information can be extracted, we hypothesize that truly noninvasive and highly sensitive devices, which exploit uniquely paired flows of at least two substances, can be developed for iontophoretic monitoring applications. Proof-of-principle targets two analytes of significant interest; specifically, glucose and lactate.