Inflammatory Gene Response in Rat Brain Following Soman Exposure

摘要

This study reports an upregulation of the neuro-inflammatory gene response using quantitative RT-PCR following soman exposure in rats. Male Sprague-Dawley rats were pre-treated with HI-6 (125 mg/kg, i.p.) and exposed 30 min later to 1.6x LD50 of soman (180 microgram/kg, s.c.) followed at 1 min by atropine (4 mg/kg, i.m.). Initially, a significant upregulation of TNF-alpha and VCAM- 1 mRNA levels were measured 2 h post-exposure followed at 6 h by IL- 1BETA, IL-6, E-selection, and ICAM-1 with resolution by 24-48 h. In conclusion, an acute upregulation of the inflammatory gene response is activated following soman exposure and may be involved in soman-induced brain injury.