Cyclin Dependent Kinase Inhibitors as Targets in Ovarian Cancer

摘要

The objective of this proposal is to develop gene therapy strategies that inhibit ovarian cancer cell growth and selectively improve sensitivity of ovarian cancer cells to chemotherapy and radiation. The proposal focuses on invitro and in vivo 'proof- of-concept' studies of target discovery. Four highly interactive projects make up this proposal. We have identified key genes that may be effective targets in ovarian cancer therapy. The first three projects seek to identify alterations in these genes which, either alone or in combination with chemotherapy or radiation, will efficiently kill ovarian cancer cells. Project 4 will identify promoters that allow for high expression of our key gene(s) in ovarian cancer cells but minimal expression in normal tissues.