Position Emitter I124 Iododeoxyuridine as a Tracer to Follow DNA Metabolism on Scans and in Tumor Samples in Advanced Breast Cancer: Comparison of 18F 2-Fluror-2-Deoxy-(D)-Glucose, as a Tracer for Glycolysis

摘要

The objectives of this study are: (1) to determine whether the biologic activity of advanced breast cancer as measured by retention of 124I IUDR on PET scans pre and post systemic therapy is different between patients whose tumor shrinks in comparison to those whose tumor is stable or grows, (2) to compare pre and posttreatment results of FDG-PET scanning and IUDR-PET scanning in the same breast cancer lesions as a basis for assessment of the metabolic change during systemic therapy, (3) to further assess the biologic activity of metastatic tumor sites and their change in size following systemic therapy by PET scans in comparison with other standard parameters such as CT and bone scans.