Advanced Optical Technologies for Defense Trauma and Critical Care.

摘要

Work under this center grant consisted of 9 projects directed toward the development and translation of biomedical photonics technologies to address Joint Force Health Protection (JFHP) capability gaps for combat trauma and critical care that have been identified by the Secretary as requiring medical R&D. These efforts include Diffuse Optical Spectroscopy (DOSI) detection for hemorrhagic shock, cytochrome c oxidase, and dehydration; Optical Coherence Tomography (OCT) and Multiphoton Microscopy (MPM) for evaluation of airway injury; Spatial Frequency Domain Imaging (SDFI) and Laser Speckle Imaging (LSI) for imaging of burns, wounds and reconstructive surgery; a continuous, real time, minimally invasive Lactate/pCO2/pO2 patient sensor; and assessment of nitrosyl-cobinamide with and without low level light therapy for acceleration of wound healing.