Development of General Antibiotics Against Known and Unknown Pathogens

摘要

The initial synthetic work was started at April of 2003. The primary objectives were to synthesize hybrid sugar and aminoglycoside antibiotic with N- 1 modification. The synthesis of pyranmycin with hybrid sugar has been accomplished. The synthetic approach of N-1 modification has yielded several aminoglycosides that are active against various resistant bacteria. In addition we have devoted effort for the development of kanamycin class aminoglycosides. Several compounds with low micromolar activity against resistant bacteria have been synthesized.