Integration of Biological Specificity with Solid-State Devices for Selective Chemical Sensing.

摘要

We investigated DNA oligomers as sorptive materials for miniature, solid-state electronic chemical sensors. We demonstrate successful integration of DNA with solid-state sensors using composites of DNA functionalized nanoparticles as chemiresistor devices. We investigated the scaling of chemiresistors down to nanometer dimensions. We demonstrate integration of many different sensing materials onto a single sensor chip. We demonstrate a path to combine a large number of DNA aptamers with nanoscale device arrays to achieve integrated, solid-state, sensor chips with specificity.