Over View of the Continuation of the Work of the Mustard Consortium for the Use of the Free and Liposome Encapsulated Antioxidants as a Counter Measure to Mustards

摘要

The Mustards Consortium has utilized both in vivo and in vitro models simultaneously to continue to elucidate mustard gas pathophysiology. In previous work done by the MC it was found that CEES, the mustard analogue, induced oxidative stress and was its primary mechanism of action. Consequently, NAC (N-acetylcystiene) was found to be protective as a prophylaxis and treatment. A combination of a water and fat soluble antioxidant encapsulated in a liposome (STIMAL) was found to have the best ameliorative effect against CEES> We have initiated development of next generation STIMAL, in order to optimize its ameliorative effect. The mechanism of action of the antioxidants is suspected to be primarily by their effect on redox regulated pathways. In an effort to elucidate the mechanism of action of the antioxidants and the pathophysiology of mustards, profiles are being developed for: gene expression and antioxidant levels, as well as biochemical pathways.