Derivation of Double-Targeted Adenovirus Vectors for Gene Therapy of Prostate Cancer

摘要

The subject of these studies is the development of targeted vector for selective infection and killing prostate cancer cells. The resultant vector is to be administered to prostate cancer patients to find, infect and destroy tumor cells. Targeting of the vector to prostate tumors is to be accomplished via incorporation into its capsid of ligands, which selectively bind to prostate-specific membrane antigen (PSMA).