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Whole Genome Sequencing of High-Risk Families to Identify New Mutational Mechanisms of Breast Cancer Predisposition.

机译：高风险家系的全基因组测序鉴定乳腺癌易感性的新突变机制。

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Walsh, T.; King, M.;
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年度 2015
页码 1-10
总页数 10
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正文语种 eng
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1. Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition. [J] . Garcia MJ, Fernandez V, Osorio Carcinogenesis . 2009,第11期

机译：FANCL，FANCM和最近鉴定出的FANCI的突变分析表明，在13个已知的Fanconi贫血基因中，只有FANCD1 / BRCA2在高危乳腺癌易感性中起主要作用。
2. High throughput fluorescence-based conformation-sensitive gel electrophoresis (F-CSGE) identifies six unique BRCA2 mutations and an overall low incidence of BRCA2 mutations in high-risk BRCA1-negative breast cancer families. [J] . Ganguly T, Dhulipala R, Godmilow L, Human Genetics . 1998,第5期

机译：基于高通量荧光的构象敏感性凝胶电泳（F-CSGE）在高风险BRCA1阴性乳腺癌家族中鉴定出六个独特的BRCA2突变，且BRCA2突变的总体发生率较低。
3. BRCA1/2 mutation screening in high-risk breast/ovarian cancer families and sporadic cancer patient surveilling for hidden high-risk families [J] . Dace Berzina, Miki Nakazawa-Miklasevica, Jekaterina Zestkova, BMC Medical Genetics . 2013,第1期

机译：高危乳腺癌/卵巢癌家庭的BRCA1 / 2突变筛查以及针对隐藏的高危家庭的零星癌症患者进行监测
4. Identifying Candidate Cancer Genes Based on Their Somatic Mutations Co-Occurring with Cancer Genes in Cancer Genome Profiling [C] . Zhu Jing, Shen Xiaopei, Zhang Yang, International Conference on Biomedical Engineering and Informatics;BMEI '09 . 2009

机译：基于与癌症基因组分析中的癌症基因同时发生的体细胞突变来鉴定候选癌症基因
5. BRCA1 mutations and polymorphisms in African American women with a family history of breast cancer identified through high throughput sequencing. [D] . Xia, Lucy Yining. 2002

机译：通过高通量测序确定患有乳腺癌家族史的非洲裔美国女性中的BRCA1突变和多态性。
6. BRCA1/2 mutation screening in high-risk breast/ovarian cancer families and sporadic cancer patient surveilling for hidden high-risk families [O] . Dace Berzina, Miki Nakazawa-Miklasevica, Jekaterina Zestkova, 2013

机译：高危乳腺癌/卵巢癌家庭的BRCA1 / 2突变筛查以及针对隐藏的高危家庭的零星癌症患者进行监测
7. Screening for Genomic Rearrangements in Families with Breast and Ovarian Cancer Identifies BRCA1 Mutations Previously Missed by Conformation-Sensitive Gel Electrophoresis or Sequencing [O] . Unger, Meredith A., Nathanson, Katherine L., Calzone, Kathleen, 2000

机译：在患有乳腺癌和卵巢癌的家庭中进行基因组重排的筛查可确定以前因构象敏感的凝胶电泳或测序而遗漏的BRCA1突变。
8. Whole Genome Sequencing of High-Risk Families to Identify New Mutational Mechanisms of Breast Cancer Predisposition. [R] . King, M., Walsh, T. 2015

机译：高风险家系的全基因组测序鉴定乳腺癌易感性的新突变机制。

Whole Genome Sequencing of High-Risk Families to Identify New Mutational Mechanisms of Breast Cancer Predisposition.

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