Cognitive Performance, Quality of Life, and Psychosocial Adjustment Among Men Receiving Androgen Deprivation Therapy for Treatment of Prostate Cancer

摘要

The goal of the original research study proposed in this postdoctoral training grant were to (a) determine the prevalence and degree of cognitive impairment in men receiving androgen deprivation therapy (ADT) for treatment of PC relative to age-matched norms; and (b) determine whether cognitive impairment in men receiving ADT is more severe than that of PC patients who are not receiving ADT. In addition, this pilot study examined relationships between subjective reports of cognitive impairment and objective measurement of cognitive performance, and assessed relationships among fatigue, psychological distress, quality of life (QOL) and cognitive function. Objective cognitive performance, subjective cognitive complaints, fatigue, and distress did not differ between men receiving ADT and controls. Men in both treatment groups experienced clinically meaningful deficits in cognitive function relative to norms.