Effect of Dietary Intervention on Prostate Tumor Development in Tramp Mice

摘要

Prospective studies indicate that as body weight and/or energy intake increase so does the risk for prostate cancer. A protective effect of energy restriction on development of spontaneous prostate tumors in Lobund- Wistar rats and tumors developing from transplanted prostate tumor tissue or cells in mice and rats have been published, but a mechanism of action has not been identified. Recent introduction of the TRAMP (transgenic adenocarcinoma mouse prostate) mouse provides a model that shares characteristics with human prostate cancer. Here, TRAMP mice are being used to evaluate their response to chronic and intermittent calorie restriction. The insulin like growth factor (IGF) axis is being investigated to determine if it is involved in this protective process. TRAMP mice are enrolled in adlibitum-fed, intermittent- restricted and chronic restricted groups in both longitudinal and cross sectional study to determine prostate cancer incidence, latency and metastasis rate, A 25% reduction in caloric intake is being utilized. Initial findings indicate that more of the intermittent-restricted mice are surviving until the designated end point of the study. Evaluation of histopathology is underway and we are attempting to identify a metabolic pathway to target for prevention and/treatment strategies.