Biomarkers of Selenium Chemoprevention of Prostate Cancer

摘要

A major goal of this project is to identify suitable biomarkers of selenium chemoprevention in human prostate cell models. These selenium- responsive biomarkers should be: (i) associated with the molecular mechanism of selenium chemoprevention, (ii) changed in a manner that is consistent with cancer risk reduction, and (iii) easily quantifiable in biopsied samples. We used the cDNA microarray technology to identify these biomarkers because it enables us to simultaneously monitor the expression pattern of a wide spectrum of genes in a single experiment.