Desmopression Prevents Immersion Diuresis and Improves Physical Performance After Long Duration Dives

摘要

Water immersion causes dehydration affecting blood flow to muscle, skin and reduces blood volume. Desmopressin inhibits urine production preventing immersion-induced blood volume loss. This study had two goats (1) examine the effect of Desmopressin on immersion diuresis and (2) any subsequent effects on physical and cognitive performance. Twenty U.S. Navy divers participated in a pool study (72 deg F) and field study (80-82 deg F) for 3.5 hat 10-15 feet of seawater; each completed a control and experimental dive. Hydration and performance were measured. Before the experimental dive, subjects received 40 microg of Desmopressin intranasally. Before and after each dive blood samples were taken, performance assessments were performed, and urine, electrolyte and hematologic values were determined. Desmopressin reduced immersion diuresis while maintaining post dive physical performance. Desmopressin significantly attenuated immersion diuresis and maintained aerobic capacity during 3.5 h dives in warm water.