New Marker for Tamoxifen Resistance in ER-Dependent Breast Cancer

摘要

While the significance of the protein kinase AKT expression lactivity in human breast cancer has become increasingly evident, consistent alterations of a specific isoform have not been well documented, A specific isoform of AKT may be preferentially activated or activated proteins may have different substrate preferences, providing a therapeutic opportunity to target a particular isoform. Previously, we have demonstrated a cross-talk between the growth factor and estrogen transduction pathways, converging in the ErbB2/PI 3- K/AKT1 signaling.