Study of Transrectal Tumor Oxygen Measurements in Patients with Clinically Localized Prostate Cancer.

摘要

This study of tumor hypoxia in prostate cancer patients has completed accrual and has yielded the largest cohort of its type world-wide. It has provided valuable information about the distribution of hypoxia in both malignant and non-malignant regions of the prostate gland the relationship between hypoxia and other important clinical and surgico-pathologic prognostic factors and the impact of androgen withdrawal on prostate cancer hypoxia. It has also provided a unique platform for investigating intrinsic biologic markers of tumors hypoxia and the relationship between hypoxia DNA repair and radioresistance in a truly relevant clinical context. Information about the relationship between hypoxia and patient outcome will follow at a later time once sufficient patient follow-up is achieved.