Role of Cdc25C Phosphatases in Human Breast Cancer

摘要

A summary is presented of research performed during the first year of a project to determine the role of Cdc25 phosphatases in human breast cancer. Three specific aims are being pursued. The first is to determine the role of Cdc25B in breast cancer proliferation. The second aim is examining whether alternative splicing of Cdc25C contributes to human breast cancer. The final aim is to explore a potential novel breast cancer therapy involving altered expression of Cdc25C. The long term goals of this research is to validate a clear role for Cdc25B in breast tumor cell proliferation and to rigorously determine whether Cdc25C may contribute to human breast tumorigenesis in other ways besides its overexpression.