Use of a Low-Concentration Heparin Solution to Extend the Life of Central Venous Catheters in the African Green Monkeys (Chlorocebus aethiops)

摘要

Normal hematological values for African green monkeys have been reported, but these results are confounded by the effect of chemical restraint (ketamine), physical restraint, and capture stress. The dual-lumen central venous catheter, jacket, and tether combination described allows intravenous fluid administration and repeated blood sampling without using restraint or anesthesia. The use of a low-concentration heparin solution for catheter maintenance resulted in a significant increase in mean patency time compared to a saline-only catheter flush solution. Adding a low-concentration heparin solution creates a suitable system for long-term, serial blood collection in the African green monkey.