Characterization of Breast Masses Using a new Method of Ultrasound Contract Agent Imaging in 3D Mapping of Vascular Anomalies

摘要

Doppler ultrasound and other imaging modalities have been used to assess characteristics of vasculature associated with malignant breast masses. 3D contrast refill imaging should help visualize slow-flow in small neo- vasculature associated with these masses. The dual-transducer method investigated is expected to provide vascular mapping while minimizing acquisition time, the major limitation of techniques such as interval-imaging (I-I) and real-time (RT) imaging. Phantom tube-flow studies confirmed the method as viable in a simple sense. Further experiments with an in vitro fixed porcine kidney provided the bulk of the data post Y2. Image volumes reconstructed using the dual-transducer method displayed remarkable spatial detail. A parametric method of visualizing mean transit times (MTTs) throughout a volume was developed, and a secondary scheme for extending the technique into clinical trials was developed. Simple MTT estimates were extended into actual perfusion estimates, using large vessel reference signals within each image plane. These signals were characterized and quantified by way of a variety of means presented in this report. There was significant consistency among methods. Results over the course of the study have been promising, and clinical trials are expected in the near future.