Proof of Concept for Systematic Collection of Optimal Molecular Quality Anatomically Oriented Normal Prostate from Diverse Age and Race Transplant Donors

摘要

The bulk of valuable molecular research published in prostate cancer to date is based on radical prostatectomy specimens from men with prostate cancer, or on metastatic prostate cancer tissues collected at surgery or autopsy. The majority of normal control tissues for such studies come from the same radical prostatectomy specimens, and less commonly from TURP (transurethral resection of the prostate) samples from men with benign prostatic hyperplasia, cystoprostatectomy specimens in men with bladder cancer, or rarely from autopsy samples collected no sooner than 12-24 hours after death, although documentation is usually absent or scant2-5. Using noncancerous areas of radical prostatectomy specimens or samples from men with other GU diseases as normal control tissue has critical drawbacks. Prostate cancer is often multifocal when it arises6-11, and there is strong evidence that precancerous changes occur gradually over a period of years in men predisposed to the disease5,12-14. Based on these observations, the noncancerous areas of prostates of men with prostate cancer are probably in a state more prone to the development of cancer than men of the same age and race without prostate cancer. Therefore, having a population-based sample of prostates from men of various ages and races is essential for us to understand whether this critical difference exists.