Methods to Protect from Skeletal Cardiovascular Insufficiency: Improving Soldier Performance in Adverse Environments

摘要

The main objective of the project is to study the cardiovascular and skeletal muscle protective actions of purines. The pre-clinical animal work has resulted in the establishment of a quantitative mouse hindlimb model of ischemia-reperfusion injury and elucidation of the role of adenosine receptor subtypes in mediating a skeletal muscle protective effect. The study demonstrated for the first time a novel protective action of the adenosine A3 receptor. It also confirmed, in this model, a protective effect of the adenosine A1 receptor. The significance is that the studies identified the adenosine A3 receptor as a new therapeutic target for the treatment of skeletal muscle ischemia-reperfusion injury. Agonists at the adenosine A3 receptor are potentially novel agents to ameliorating skeletal muscle injury. The clinical works have also begun to test the genetic polymorphism of adenosine transporter and its biological significance. At this point, we have identified several polymorphisms, some are non-synonymous and cause missense mutations.