Prognostic Value of Allelic Imbalance in Prostate Biopsy

摘要

Purpose: The novel Concept that is being tested in this project is that allelic imbalance (Al) in tissue obtained at prostate biopsy can serve as a sensitive and independent marker for staging and predicting disease recurrence in prostate cancer. Scope: The two Aims of the project are to(i)determine whether the number of sites of Alin biopsy predicts pathological staging following prostatectomy and (ii) to determine the independence, positive and negative predictive values, sensitivity of Al in biopsy tissues as a prognostic marker for prostate cancer. Major Findings: The number of sites of Al has been measured in DNA from 131 prostatectomy tissues, 102 tumor adjacent, histologically normal prostate tissues, 75 biopsy specimens with a positive diagnosis of prostate cancer, 22 tumor adjacent, histologically normal biopsy specimens and II normal prostate tissues from men without disease. The results demonstratethat Al is increased (i)in tumor and tumor-adjacent prostate tissues relative to normal prostate tissues, (ii) as a function of Gleason Sum and (iii)in recurrent prostate tumors. Significance: Allelic imbalance in prostate cancer tissues may provide a novel diagnostic and prognostic marker.