Superoxide Dismutase and Transcription Factor sox9 as Mediators of Tumor Suppression by mac25 (IGFBP-rp1) in Prostate Cancer Cells

摘要

The most significant conclusion that is going to be derived from the work on this proposal is the relationship of tumor cell contribution to the extra cellular environment and tumor growth. This was unexpected when we started this proposal and this work has not been completed. However, based on the findings generated in this DOD proposal Dr. Plymate has received a 5 yr NCI/NIH U54 Program Project to further develop these interactions.