Human CD1d-Restricted Natural Killer T (NKT) Cell Cytotoxicity Against Myeloid Cells

摘要

CD1d-restricted natural killer T cells (NKT cells) are a unique subpopulation of T lymphocytes that have been shown to be able to promote potent anti-tumor responses in a number of different murine (mouse) cancer models, Little is known about whether they may play a role in preventing or controlling human cancers and in particular there is little information about whether they can function to kill cancer cells as they arise Iin vivot (in the body) However it is clear that tin vitrot (in the test tube) NKT cells have the capacity to kill other cells that have a molecule called CD1d on their cell surface, One of the main human cell types that have CDId on the cell surface are cells of the myeloid lineage Thus we believe that NKT cells may have special potential for treating CML because they may be able to kill these tumor cells and it may be possible to devise a protocol to specifically stimulate the NKT cells to kill CML tumor cells as they begin to proliferate.