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Cell-Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer.

机译：细胞穿透双特异性抗体靶向晚期前列腺癌的致癌转录因子。

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作者
Lilly, M.;
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年度 2015
页码 1-8
总页数 8
原文格式 PDF
正文语种 eng
中图分类
关键词
Prostate cancer; Androgens; Receptor sites(physiology); Antibodies; Inhibition; Proteins; Cells(biology); Lesions; Transcription (genetics); Oncogenesis; Ar(androgen receptors); Bi-specific antibodies; Oncogenic transcription factors;

机译：前列腺癌;雄激素;受体位点（生理学）;抗体;抑制;蛋白质;细胞（生物学）;病变;转录（遗传学）;肿瘤发生; ar（雄激素受体）;双特异性抗体;致癌转录因子;

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1. Development of cell-penetrating bispecific antibodies targeting the N-terminal domain of androgen receptor for prostate cancer therapy [J] . Goicochea Nancy L., Garnovskaya Maria, Blanton Mary G., Protein engineering design & selection: PEDS . 2017,第11a12期

机译：靶向雄激素受体N-末端结构域的细胞穿透双特异性抗体进行前列腺癌治疗
2. Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. [J] . Stolzenburg S, Rots MG, Beltran AS, Nucleic Acids Research . 2012,第14期

机译：乳腺癌中致癌转录因子SOX2的靶向沉默。
3. Integrated molecular dissection of the epidermal growth factor receptor (EFGR) oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer. [J] . Sartore Bianchi A, Bencardino K, Di Nicolantonio F, Targeted oncology . 2010,第1期

机译：表皮生长因子受体（EFGR）致癌途径的综合分子解剖，可预测转移性结直肠癌对EGFR靶向单克隆抗体的反应。
4. Imaging Small Prostate Cancer Lesions Pretargeted with Bombesin-Bispecific Antibody Complexes and Tc-99m Labeled Polymer Drug Conjugates. [C] . Patil, Gada, Panwar, Annual meeting exposition of the Controlled Release Society . 2011

机译：成像的小前列腺癌病变预先靶向有Bombesin-双特异性抗体复合物和Tc-99m标记的聚合物药物缀合物。
5. Transcription cofactor LBH is a direct target of the oncogenic Wnt pathway with an important role in breast cancer [D] . Rieger, Megan E. 2010

机译：转录辅助因子LBH是致癌Wnt途径的直接靶标，在乳腺癌中具有重要作用
6. Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2 allowing target gene activation [O] . Vivekananda Kedage, Brady G. Strittmatter, Paige B. Dausinas, 2017

机译：前列腺细胞中致癌转录因子ERG的磷酸化可解离多梳抑制复合物2从而激活靶基因
7. A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer. [O] . Campa VM, Baltziskueta E, Bengoa-Vergniory N, 2014

机译：糖原合成酶激酶-3转录因子靶标的筛选突出了前列腺癌中NFκB和雄激素受体信号传导的逆相关性。
8. Cell-penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer. [R] . Lilly, M. 2014

机译：细胞穿透双特异性抗体靶向晚期前列腺癌的致癌转录因子。

Cell-Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer.

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