Molecular Characterization of Prostate Cancer Cell Oncolysis by Herpes Simplex Virus ICP0 Mutants

摘要

This final report outlines the progress made on our Exploration: Hypothesis Development Award over the past 18 months. Briefly, the goals of the proposal were to characterize the oncolytic capacity of Herpes simplex virus type 1 ICP0 mutants in prostate cancer cells given the relationship between ICP0 and two tumor suppressors, RNase L and PML, implicated in prostate cancer progression. We recently published that ICP0 prevents an RNase L-independent rRNA degradation event in infected cells (Journal of Virology, 2006). We also provide preliminary evidence that suggests that the ability of ICP0-null HSV-1 mutants to selectively kill prostate cancer cells correlates with both a reduction in PML levels and the status of interferon signaling within each cancer line.