Synthesis of Diketopiperizine Peptide Derivatives by Cross-Metathesis

摘要

The olefin CM reactivity and selectivity of amino acid derivatives with a cyclic scaffold to generate diketopiperizine peptide derivatives were investigated. Product yields were dependent on the amino acid R groups, and whether the amino acid possessed an allyl or homoallyl moiety at the caroxylate side. The stereoselectivity of the dipeptide derivatives was found to be predominantly trans.