Societal Interactions in Ovarian Cancer Metastases: Quorum-Sensing Hypothesis; Annual rept. 1 Nov 2005-31 Oct 2006

摘要

It is unknown what specific biochemical and biological mechanisms control ovarian cancer metastasis. Uncovering the mechanism(s) responsible for regulating metastatic colonization in ovarian cancer requires a fresh look from a new perspective. The purpose of this work is to test a completely novel hypothesis: That a Quorum Sensing mechanism is involved in metastatic colonization. Quorum sensing is a process of cell-cell communication that bacteria use to control gene expression in response to fluctuations in cell population density.